In a match that has ramifications for how the Cricket Shepparton Haisman Shield finals shapes up, Nolan's unbeaten 73-run knock was the highlight of Nagambie's total of 158.
The importance of Nolan's half-century is highlighted by the fact he came out to bat with the Lakers 1-2 and slogged it out in the middle to be the last man standing for the visitors.
Saturday's knock was Nolan's second half-century of the season and followed on from his unbeaten 41 in last round's loss to Old Students.
Kyabram's spearhead bowlers Jackson and Charlie McLay did the early damage in the round 13 contest to leave Nagambie 3-11 and with star batsman and Nolan's brother, Mark, back in the sheds.
A resilient 18-run knock from Matt Martin helped Nagambie reach 46, however, a Lukas Hanslow (1-4) delivery ended his innings.
Nolan's next batting partner Brayden Biggs (15 runs) stuck around for the next 44 runs, but his dismissal triggered a mini collapse.
The Lakers lost 4-9 in quick fashion as Jackson (4-16) ripped through the tail-order to leave the away side struggling at 8-99.
But a brave performance from No. 11 bat Nathan Fothergill (19 runs) ensured the Lakers reached a total for its bowling brigade to try and defend.
Two late wickets to Jackson's brother Charlie (3-51) was the cherry on top in a dominant performance for the home side.
STATE OF PLAY
Nagambie 158 (Luke Nolan 73, Nathan Fothergill 19, Matt Martin 18, Brayden Biggs 15, Jackson McLay 4-16, Charlie McLay 3-51)
STAR PLAYER
Luke Nolan (Nagambie): Nolan's tough and gritty 73-run knock was the glue that kept Nagambie's first innings from falling to pieces. The gun wicketkeeper-batsman relished the pressure scenario and hung in for a memorable knock.