With the league's top-ranked side taking on the bottom team, the Blues will be out to address recent struggles in two-day matches, where they have won just two of their four two-dayers this season.
That includes last round's disappointing showing against Kyabram, where the Blues could manage just 139 with the bat as their middle-order failed to fire.
Dylan Grandell (479 runs at 43.5) carved 66 to continue good form, while the fearsome middle-order of Shaun Downie (330 at 33), Michael Eckard (327 at 40.9) and Liam Gledhill (232 at 38.7) will look to regain great form.
The Blues have essentially already locked in top spot on the ladder, only able to drop out of first should either Kyabram and Mooroopna record an outright win combined with a Numurkah loss.
It is beautifully positioned heading into finals, almost certain to have a home final and a double-chance in the first round.
For Tatura, it will have one last chance to avoid going a season without a win, but it will need a huge improvement to match it with the Blues after outright defeat to Mooroopna last weekend.
While captain Michael Archer (283 at 28.3) has proved tough to dismiss all season, the Bulldogs lost 20 wickets in 82 overs against the Cats and must dig in to avoid a similar situation against the fierce Blues.