The crash happened on the Hume Hwy just south of Violet Town around 2.30pm.
All lanes are closed and detours have been set up for all traffic, with significant delays in both directions approaching the collision scene.
Th highway is closed between Harry’s Creek Rd and Quarry Rd, at Violet Town.
Drivers heading north (away from Melbourne) should detour from the Hume Fwy in Seymour using the Goulburn Valley Hwy to Shepparton. Then use the Midland Hwy from Shepparton to Benalla to re-join the Hume Fwy.
Drivers heading south (toward Melbourne) should detour at Violet Town and use the Murchison-Violet Town Rd through Miepoll to meet the Goulburn Valley Hwy, then travel south to Seymour to re-join the Hume Fwy.
There are areas of roadworks along the detour routes. Please obey all sign posted speed limits, drive to the conditions, and stay alert for emergency services.
Victoria Police and emergency crews are attending and the Hume Fwy will re-open only when it is safe to do so.
The closure is expected to be in place for a significant period.
Transport Victoria provides real-time traffic conditions and the latest public transport information at transport.vic.gov.au/
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