Councillors will hear a recommendation by the planning department to approve the $30 million development between Mooroopna and Kyabram.
Meatworks Australia is planning a development on a former dairy farm which will slaughter up to 3000 sheep a day and employ up to 120 people.
The EPA has issued a works permit for the site at 630 Lancaster-Mooroopna Rd.
Some nearby landholders have objected to the development on land zoned for farming.
The facility will operate about 275 days per year from Monday to Friday, 12 hours per day (and some Saturdays) with a period of shutdown for maintenance.
EPA executive director Tim Eaton said the works approval application was thoroughly assessed and took into account the findings of a community conference.
“EPA received 16 submissions on the proposal and held a community conference to further discuss these and work through possible solutions and mitigation measures,” Mr Eaton said.
“The key environmental issues raised by the public were about potential odour, noise and dust, and health impacts from livestock.
“EPA has determined that with controls and suitable works approval conditions the environmental risk can be acceptably managed.”