Four Australian citizens, one permanent resident and one New Zealander, who were evacuated from the MV Hondius cruise ship, landed at RAAF Base Pearce near Perth about 1pm AEST on Friday.
The group will be placed in quarantine at the Centre for National Resilience next to the base for at least three weeks.
All passengers are in good health and showed no symptoms, Health Minister Mark Butler said on Thursday.
Three of the passengers live in NSW while the other two reside in Queensland.
It is unclear when they will be permitted to return home as their quarantine could be extended pending advice from chief health officers.
The biggest risk to Australians was not posed by this cohort, but by those who had been exposed to hantavirus and failed to undergo quarantine, University of the Sunshine Coast associate professor Erin Price said.
"The concern is really for people travelling," Prof Price told AAP.
"Some of the passengers who were on this cruise ship disembarked before the outbreak was identified and have moved quite a bit around the world.
"That is a real worry."
The MV Hondius docked in Tenerife on Sunday after three people died and others were confirmed to have tested positive for the virus, which is contracted through contact with infected rodents.
The Andes form of hantavirus that caused the cruise ship outbreak can be transferred from person to person through bodily fluids, including saliva, blood and urine.
People have been urged to wear a P2 respirator - also known as an N95 respirator - in public spaces such as aircraft to prevent them from inhaling the virus particles.
Blue surgical masks will not stop any viruses, Prof Price said as she stressed the importance of respirators.
The virus is also susceptible to alcohol-based hand sanitisers, so Prof Price has recommended regular handwashing with soap, wiping down surfaces and other regular hygiene practices such as washing clothes and having a shower after a flight.
Symptoms can occur one to eight weeks after exposure and the window of infection is believed to be four days, including two days during which those afflicted can be asymptomatic, Prof Price said.
Hantavirus is not as infectious as COVID-19 but its long incubation period could still pose issues, fuelling calls for clear, consistent and science-based messaging from governments to mitigate risks.
Early symptoms are flu-like and include fevers, fatigue, muscle aches, headaches, chills or dizziness.
Some from the cruise have also experienced gastrointestinal symptoms such as diarrhoea, vomiting and nausea.
If the virus becomes severe, those infected can become short of breath as their lungs fill up with fluid, leading to reduced oxygen levels, low blood pressure, heart issues and sometimes death.
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