Shubman Gill (29 not out off 13 deliveries) and Abhishek Sharma (23no off 13) tore into the Australia attack in the opening 4.5 overs.
Abhishek was dropped twice and rode his luck.
A lightning strike in the vicinity of the ground forced the players off before the covers were placed on the pitch ahead of a large rain band approaching from Brisbane's west.
A washed-out match would hand India a 2-1 series win.
Gill was a man on a mission from the get-go before the players left the field.
His timing for six boundaries was immaculate.
Unlucky Ben Dwarshuis had a sense of deja vu in the opening over when Abhishek was dropped at mid-off by the usually reliable Glenn Maxwell.
Abhishek was also dropped in the first over, off the same bowler, two days earlier on the Gold Coast when India secured a 48-run win.
To rub salt into the wounds, Dwarshuis then spilled a sitter himself at fine leg when Abhishek had made just 12, this time off the bowling of Nathan Ellis.
The world's No.1-ranked T20 batter then dispatched Ellis for a massive six over midwicket.
Australia elected to bowl first and named an unchanged side in their quest to level the T20 series.
Captain Mitch Marsh, probably with an eye towards the storm, chose to chase a target.
India won game four on Thursday night after Australia collapsed against a three-pronged spin attack at Carrara.
Both teams are aiming to find out more about their best combinations with the T20 World Cup in India and Sri Lanka set to be held in February and March of next year.
India made just the one change to the side that won the penultimate game of the series with middle-order batter Rinku Singh coming in for the rested Tilak Varma.
