Tom De Koning, Lachie Plowman, Lachie Fogarty, Jordan Boyd and Lochie O'Brien were all dropped, while captain Patrick Cripps was ruled out with a hamstring injury.
The Blues welcome back ruckman Marc Pittonet, while Matthew Cottrell, Corey Durdin, Jack Newnes, and Luke Parks were also included.
Port Adelaide have lost ruckman Scott Lycett for three months to a shoulder injury, while star midfielder Ollie Wines is out following last week's heart scare.
Power defender Lachie Jones has been forced into the AFL's health and safety protocols, while Sam Mayes and Jed McEntee were dropped.
Forward Jeremy Finlayson returns following a six-goal haul in the SANFL last week, while stars Aliir Aliir and Robbie Gray are back.
Sam Hayes, the 47th pick in the 2017 national draft, has been named for his debut as Lycett's replacement.
Fremantle have been boosted by the return of defender Alex Pearce (ankle) and midfielder Caleb Serong (knee) for Sunday's match against Essendon at Marvel Stadium.
Forward Lachie Schultz (protocols) was forced out, while Griffin Logue was dropped to make way for Pearce's return.
The Bombers have handed a debut to midfielder Ben Hobbs, who was selected with pick No.13 in last year's national draft.
Nik Cox was also included, with Will Snelling (calf), Brayden Ham (dropped), and Tex Wanganeen (dropped) all going out.
Meanwhile, Hawthorn star Chad Wingard will not play in the Easter Monday match against Geelong.
Wingard was an inclusion in the extended squad after missing the week before with a calf injury.
But the Hawks pulled him out on Friday, again because of injury, and Max Lynch will take his place, with the final teams yet to be confirmed.
The Cats are set to regain star defender Tom Stewart, who was a late withdrawal last week because of illness.
"It was really bad timing - 12 hours earlier or 12 hours later and he would have been fine," coach Chris Scott said on Friday.
"The feedback I have is that he's recovered quickly and he's ready to go."
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