Scotland's Blair Kinghorn replaces James Lowe on the left wing and Irishman James Ryan replaces Ollie Chessum in the second row for the third Test in Sydney on Saturday night.
Ryan become skipper Maro Itoje's third different starting Test partner in the second-row, Chessum and Joe McCarthy being the others.
Chessum drops to a bench that has a six-two split between forwards and backs. Lowe, who has not played to his usual high standard, is out of the squad entirely.
Owen Farrell and Alex Mitchell are the two backs on the bench, Farrell covering 10 and 12.
Jac Morgan, who made the controversial clean out before the Lions' match-winning, last-gasp try in the second Test at the MCG, is again poised to come off the bench, with Tom Curry retained in the No.7 starting role.
The line-up means 11 players have been chosen to start all three Tests.
Farrell's men are aiming to be the first Lions squad to record an unbeaten tour since the 1974 outfit, which finished with a 13-13 draw in the third Test against the Springboks, and the first to sweep a three-Test series since the lopsided victories in Argentina in 1927.
"We have put ourselves in position to finish this tour with our best performance to date and create our own piece of history," Farrell said. "Last weekend's Test match was an increadible spectacle. We are expecting another epic battle this weekend."
Hooker Dan Sheehan is starting again alongside Irish teammate Tadhg Furlong, who is starting his ninth consecutive Lions Test, and said before the squad was announced that there'd be no relenting from the tourists.
"We've always been pretty clear on our goals — to go unbeaten overseas and win the series 3-0," he said. "So we just need to stick to what we said."
For the Lions, the halves pairing of Finn Russell and Jamison Gibson-Park has been pivotal to their success in both Tests so far, along with a consistent backrow featuring No. 8 Jack Conan and flankers Curry and Tadhg Beirne.
In 2001 and 2013 the Lions lost in Melbourne after winning the first match of a three-Test series against the Wallabies and those series went to a decider in Sydney. A sweep is on the minds of both teams this time in what will be a sold-out Accor Stadium.
British and Irish Lions: Hugo Keenan (Ireland), Tommy Freeman (England), Huw Jones (Scotland), Bundee Aki (Ireland), Blair Kinghorn (Scotland), Finn Russell (Scotland), Jamison Gibson-Park (Ireland); Jack Conan (Ireland), Tom Curry (England), Tadhg Beirne (Ireland), James Ryan (Ireland), Maro Itoje (England, captain), Tadhg Furlong (Ireland), Dan Sheehan (Ireland), Andrew Porter (Ireland). Reserves: Ronan Kelleher (Ireland), Ellis Genge (England). Will Stuart (England), Ollie Chessum (England), Jac Morgan (Wales), Ben Earl (England), Alex Mitchell (England), Owen Farrell (England).
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