The Koreans stormed into a 2-0 lead in Saturday's quarter-final at Stadium Australia after just 20 minutes with goals from Son Hwayeo and Ko Yoojin.
The Uzbeks put up a solid fight to stem the bleeding, before Park Soojeong, Ji Soyun, Lee Eunyoung and Jang Selgi added goals in the second half in Sydney in front of 12, 974 fans.
South Korea will meet the winners of Sunday's quarter-final between Japan and the Philippines in the semi-finals in Sydney on Wednesday.
Uzbekistan, meanwhile, will play the losers of that fixture in Thursday's playoffs on the Gold Coast, where victory would secure qualification for next year's Women's World Cup in Brazil.
Korea dominated Saturday's match from start to finish and are likely to face much sterner opposition in the semi-final.
Shin Sang Woo's side had 16 shots on target to Uzbekistan's one and enjoyed 80 cent of possession.
It took little time for the Koreans to take the lead when Son cut in from the right and her shot deflected off Dilrab Asadova and into the back of the net after just nine minutes.
Ko was next to get in on the action when Sevinch Kuchkorova failed to properly clear a Korean cross and the defender rifled in from the edge of the box.
The Ubzeks held firm but were struggling to create any real opportunities to test Korean goalkeeper Ryu Jisu.
Zarina Mamatkarimova arguably had their best chance of the match on the counter just before halftime, but was unable to get a shot past Ryu.
Any faint hope of a second-half Uzbek comeback was extinguished when Park stabbed home in the 57th minute.
Ji made it four when she poked through a tight space and past Uzbekistan goalkeeper Maftuna Jonimqulova, whose heroics prevented the Koreans from running out to a double-digit lead.
Lee grabbed the Koreans' fifth of the night when she tapped in an 86th-minute rebound from close range, before Jang smashed in an added-time penalty.
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