"We said before we'd have liked Liverpool, Chelsea, Arsenal," said Macclesfield coach John Rooney, the younger brother of England great Wayne Rooney. "But another Premier League team — incredible."
Palace, the titleholder, were humbled by a team 117 places lower in English soccer's league pyramid and was one of six top-flight teams to be knocked out so far in the third round. The others were Manchester United, Tottenham, Everton, Bournemouth and Nottingham Forest.
Newly hired Chelsea coach Liam Rosenior will take his team to second-tier Hull, one of his former clubs, while Manchester City were drawn to play Salford City or Swindon — lower-league teams who meet on Tuesday. Arsenal will host third-tier Wigan.
Aston Villa will host Newcastle in the only guaranteed all-Premier League match-up. Another could see Liverpool — provided they beats third-tier Barnsley on Monday — host Brighton.
Wrexham, the second-tier team owned by Hollywood celebrities Ryan Reynolds and Rob McElhenney, were drawn at home to fellow Championship club Ipswich Town after knocking out Nottingham Forest.
FA Cup fourth-round draw:
Liverpool v Brighton
Stoke City v Fulham
Oxford United v Sunderland
Southampton v Leicester City
Wrexham v Ipswich Town
Arsenal v Wigan Athletic
Hull City v Chelsea
Burton Albion v West Ham
Burnley v Mansfield Town
Norwich City v West Bromwich Albion
Port Vale v Bristol City
Grimsby Town . Wolverhampton Wanderers
Aston Villa v Newcastle
Manchester City v Salford City or Swindon
Macclesfield v Brentford
Birmingham City v Leeds United
(Matches to be played February 13-16)