Emergency services were called to the incident at around 4.55pm on December 15 where police believe a minivan containing nine occupants was travelling along Chapel Rd before the driver lost control and crashed into a tree.
Four passengers, who are yet to be formally identified, died at the scene.
A spokesperson for Ambulance Victoria said three air ambulance helicopters, Mobile Intensive Care Ambulance and Advanced Life Support paramedic crews assessed and treated multiple patients at the scene.
A child with upper and lower body injuries was airlifted to the Royal Children's Hospital in a critical condition.
A teenage female with upper body injuries was airlifted to the Royal Children's Hospital in a critical condition.
A teenage female with upper and lower body injuries was airlifted to Royal Melbourne Hospital in a serious but stable condition.
A teenage female with upper and lower body injuries was transported by road ambulance to Goulburn Valley Health in a stable condition.
A man with upper and lower body injuries was airlifted to Royal Melbourne Hospital via fixed wing air ambulance plane in a serious but stable condition.
Major Collision Investigation Unit detectives are investigating.
The exact circumstances surrounding the crash are yet to be determined.
Anyone who witnessed the crash, has CCTV or dashcam footage, or anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at crimestoppersvic.com.au
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