Ukrainian President Volodymyr Zelenskiy said on Friday that four people had died in the attack on the capital.
Zelenskiy said Russia had launched around 430 drones and 18 missiles in overnight attacks.
"This was a deliberately calculated attack aimed at causing maximum harm to people and civilian infrastructure," Zelenskiy wrote on X.
"Ukraine is responding to these strikes with long-range strength, and the world must stop these attacks on life with sanctions."
Mayor Vitali Klitschko said 26 people were injured, four of them being treated in hospital, including a pregnant woman and one in very serious condition.
The attack on the capital was ongoing, officials said, urging residents to remain in shelters until the air raid alert is lifted.
City authorities warned that power and water outages are possible.
Ukraine's Foreign Minister Andrii Sybiha said about 30 residences were damaged, urged counterparts to swiftly implement strong measures discussed at a meeting of G7 nations in Canada.
"This brutal Russian attack demonstrates the urgent need for new contributions to Ukraine's defence and new steps to increase pressure on Russia, including the long-awaited decision on frozen assets," Sybiha wrote on X.
In the Darnytskyi district, debris landed in the yard of a residential building and on the grounds of an educational facility.
A car caught fire after being hit by falling fragments.
Debris damaged three apartment buildings, a private household and caused a fire in the Dniprovskyi district.
Five residential buildings and a non-residential structure were damaged in the Podilskyi district.
In the Shevchenkivskyi district, falling debris sparked a fire in an open area near a medical facility and inside a nonresidential building.
There were also fires burning in four other districts.
In the Kyiv region, Russian strikes damaged critical infrastructure and private homes, injuring at least one civilian, regional head Mykola Kalashnyk said.
A 55-year-old man in Bila Tserkva suffered thermal burns and was transported to hospital, he said.
Fires also broke out in private houses in the capital's suburbs.
The strike came as European Union officials warned this week that Ukraine must continue to crack down on corruption following a major graft scandal that has put top nuclear energy officials under scrutiny.
But they also offered assurances that aid will continue to flow as Kyiv strains to hold back Russia's invasion.
with Reuters
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