Ennio Morricone, whose scores for movies such as The Good, the Bad and the Ugly, The Mission and Cinema Paradiso made him one of the world's most famous and prolific screen composers, has died aged 91, ANSA news agency reports.
ANSA says Morricone, who won two Oscars and dozens of others awards including Golden Globes, Grammys and BAFTAs, broke his femur some days ago and died during the night in a clinic in Rome.
His last Oscar was in 2016 for best original score for Quentin Tarantino's The Hateful Eight.
He first declined the job but then relented, demanding Tarantino allow him a "total break with the style of Western films I wrote 50 years ago".
Morricone wrote for hundreds of films, television programs, popular songs and orchestras but it was his friendship with Italian director Sergio Leone that brought him fame, with scores for spaghetti westerns starring Clint Eastwood in the 1960s.
They include the so-called "Dollars Trilogy" - A Fistful of Dollars, For a Few Dollars More and The Good, the Bad and the Ugly.
Morricone used unconventional instruments such as the Jew's harp, amplified harmonica, mariachi trumpets, cor anglais and the ocarina - an ancient Chinese instrument shaped like an egg.
The music was accompanied by real sounds such as whistling, cracking of whips, gunshots and sounds inspired by wild animals including coyotes.
He always tried to shake off the association with the spaghetti westerns, reminding people, particularly outside Italy, that he had a very creative and productive life before and after the films he made with Leone.
One of Morricone's most evocative soundtracks was for the 1986 film The Mission, by Roland Joffe, for which he was nominated for an Oscar and won a Golden Globe.
To accompany the story of the Jesuit missions in 18th century South America, Morricone used European style liturgical chorales and native drums to convey the mix of the old and new worlds.
In Italy, Morricone developed a close friendship with director Giuseppe Tornatore, whose Cinema Paradiso won the Oscar for best foreign film in 1989.
Morricone also composed for Brian De Palma's The Untouchables, Barry Levinson's Bugsy and Margarethe von Trotta's The Long Silence.
Born in Rome in 1928, Morricone learned music from his father, a trumpeter in small orchestras.
He entered Rome's conservatory at the age of 12, studying trumpet, choral music and composition, and was chosen to join the orchestra of the prestigious Academy of Santa Cecilia.
He first wrote music for theatre and radio programs and later was a studio arranger for record labels, working with some of Italy's best-known pop stars of the 1950s and 1960s.
He ghost-composed several film scores before he received his first credit for Luciano Salce's Il Federale in 1961.
Morricone married Maria Travia in 1956. They had three sons and a daughter.