Mooroopna needs 126 runs to win when the second day resumes on Saturday at Mooroopna Recreation Reserve.
Old Students-Notre Dame-St Brendan's Tom Honey made a strong 22 not out, while teammate Nick Mori chipped in with a valuable 20 as the visitors posted 7-125 off 45 overs.
Mooroopna duo Beau Metcalf (2-6) and Ben Butts (2-5) had great days with the ball.
In other games, Tatura faces an uphill battle when day two resumes, in strife at 2-4 chasing Euroa's 144.
Youngster Ben Andonoudis spun a web on the Euroa batsmen, with the Tatura spinner claiming 3-27.
Elsewhere, ladder leader Numurkah needs a further 15 runs to grab first innings points against Pine Lodge.
The Blues rolled the Lodgers for just 40 off 36 overs and ended day one at 3-25.
Meanwhile, Karramomus needs a further 100 runs to defeat Shepparton United, set to resume at 3-18 on Saturday.
At B-grade level, Katandra posted a dominant first innings against Northeners off the back of a stunning 124-run first-wicket partnership.
Eagles Bailey Simpson (61 not out) and Talon Wilson (60 not out) were the two pillars in the 2-174 total.
The duo whacked 18 boundaries between them, while teammate Ned Walters chipped in with a handy 25 not out.
Lastly, Nagambie piled on a whopping 4-210 against Murchison.
The Lakers’ Jonathan Moore blasted 61 not out off 43 deliveries, as he flashed nine of those balls to the fence.
Angus Murray added an important 33 not out at the tail to push Nagambie past 200.
Murchison's Mitch Rowney picked up 1-15 off six overs.