A Watford fan suffered a cardiac arrest which caused the match against Chelsea at Vicarage Road to be temporarily halted on Wednesday night, while the start of the second half of Saints' clash with Leicester was delayed as a supporter was carried out of the Kingsland Stand.
Referee David Coote took both sets of players off the pitch at Watford in the 12th minute due to the medical emergency in the Graham Taylor Stand.
Medical staff from both teams raced across the pitch to assist the supporter, who was stabilised and then carried out on a stretcher to be taken to hospital.
Watford defender Adam Masina was down receiving treatment when the fan appeared to be taken ill. Fellow supporters got the attention of the players, who then waved down the medical staff.
The players were off the pitch for around 25 minutes, before returning to the field for a five-minute warm-up, and the match resumed with the clock set at 12 minutes.
Watford tweeted: "The players have returned to the field in preparation of play resuming.
"Our thoughts are with the fan - who had a cardiac arrest but has now been stabilised - and all those affected.
"Thank you to the medical staff, players and fans for their quick response."
A Chelsea statement read: "The thoughts of everyone at Chelsea Football Club are with the fan and all those affected.
"Our thanks to the medical staff here at Vicarage Road for their quick response."
Southampton's home clash with Leicester was also subject to a short delay, while medics dealt with another emergency.
A home supporter received treatment before being carried out by paramedics.
A message on the scoreboard read: "Second half delayed due to a medical incident. Thank you for your patience."
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