Brazil superstar Neymar has picked up another injury as the Selecao were held 1-1 by Nigeria in a Singapore friendly.
The Paris Saint-Germain forward limped off with a thigh injured after only 12 minutes on Sunday and was replaced by Philippe Coutinho.
Joe Aribo put Nigeria in front 35 minutes into the contest in the National Stadium but Casemiro's header three minutes after the interval ensured parity.
Brazil were also held 1-1 by Senegal in Singapore last week as the Copa America champions prepare for World Cup 2022 qualifying, which starts next year.
Neymar has recently been plagued by injuries to the foot and ankle which cost him his spot at the home Copa earlier this year.
The 27-year-old Neymar now has 101 caps for Brazil but has played only five times for PSG this season.
Since lifting the Copa America in July, Brazil have also drawn with Colombia and Senegal and lost to Peru.
Meanwhile in Alicante, Spain, Chile forward Alexis Sanchez injured tendons in his left ankle during their 0-0 draw with Colombia and has returned to his club Inter Milan for further tests.
Sanchez was fouled moments before the end of the stalemate and had to come off.
The Chilean Football Federation said he will miss Chile's friendly against Guinea on Tuesday, which will take place in the same city.
Gary Medel of Bologna will also miss the match after suffering a muscle problem in the first half against Colombia.
Also in Spain, Argentina had no trouble in dismissing Ecuador 6-1 even without suspended star Lionel Messi. The Barcelona forward is serving a ban for alleging corruption at the Copa America.
Lucas Alario opened the scoring before an own goal from Jhon Jairo Espinoza and penalty from Leandro Paredes had Argentina cruising at the break.
Angel Mena replied for Ecuador early in the second half but German Pezzella, Nicolas Dominguez and Lucas Ocampos completed the rout.