South Australia opener Jake Weatherald has tormented Tasmania for the second time this Sheffield Shield season to put his side in the box seat for a rare win.
Weatherald propped up his side with 126 on day two in Hobart, a month after notching a career-best 198 against the Tigers in Adelaide.
The 25-year-old hit 14 boundaries and shared a crucial counter-attacking 128-run stand with skipper and Australia limited-overs wicketkeeper Alex Carey (73).
"It was challenging at times, their bowlers bowled a good line and length but when there was a bad ball you could take care of it," Weatherald said.
"I probably do match up well against them. It's just fallen that way that I've made runs against them."
The Redbacks' first-innings was boosted to 346 late on Sunday after cameos from tailenders Joe Mennie (49 from 39 balls) and Nick Winter (42).
The Tigers' second innings got off to the worst possible start, losing Alex Doolan for a duck in a nervy 15 minutes before stumps.
They'll resume on day three at 1-6, still trailing by 86 runs.
Weatherald and Carey came together at 3-53 in the morning session after the Redbacks lost 3-8.
Carey fell to a sharp catch by Ben McDermott at second slip but not before posting another healthy long-form contribution after his 143 last match against Western Australia.
Test-experienced quick Jackson Bird was the pick of Tasmania's quicks with 4-70 including the scalp of Weatherald, who he trapped lbw with the second new ball.
Weatherald has amassed 328 runs against Tasmania in the Shield this season, but just 120 across four matches against other opposition.
Earlier, the winless Redbacks lost Henry Hunt (six), Callum Ferguson (0) and Will Bosisto (one) in quick succession after resuming the day at 0-26.
Youngster Daniel Drew had a debut innings to forget, out for nine when he hit a ball from Riley Meredith into the ground and it lobbed up and landed on top of the stumps.
South Australia have gone 18 Shield matches without a win, dating back to February 2018.