South Korean superstar Son Heung-min has inspired Tottenham to a crushing 3-0 win over Borussia Dortmund 3-0 at Wembley, giving Spurs a huge advantage after the first leg of their last-16 Champions League tie.
Belgian defender Jan Vertonghen set up Son for a 47th-minute opener before he notched his first goal in the Champions League with a well-timed volley in the 83rd minute.
Substitute Fernando Llorente grabbed their third in the 86th.
It was Son's ninth goal against Dortmund in 11 matches, with the South Korean, who played in the Bundesliga from 2010-15, having also scored twice in the competition's group stage last season.
"Son is a player that of course has a lot of quality and is a very talented player," said Tottenham manager Mauricio Pochettino.
"But he is always available to learn, improve and listen to what you expect from him.
"He is capable of adapting the quality in different situations."
Bundesliga leaders Dortmund, who were eliminated from the German Cup last week, were thoroughly outplayed in the second half.
Three-time defending champions Real Madrid will take a 2-1 lead back to the Bernabeu after they edged Ajax 2-1 at the Amsterdam Arena.
After a goalless first half, goals from Karim Benzema (60th) and Marco Asensio (87th) either side of Hakim Ziyech's strike in the 75th minute gave Real the victory.
Ajax were denied a first-half opener when the video assistant referee (VAR), for the first time in the Champions League, ruled out a goal.
Nicolas Tagliafico headed home only for Slovenian referee Damir Skomina to check with the VAR and adjudge Dusan Tadic offside.
Both return legs will be played on March 5.
Tottenham, playing without injured captain Harry Kane and Dele Alli, had never previously won a home match in the knockout stage of the competition.
Lucas Moura came close with a fine shot in the seventh minute.
Dortmund, who were themselves missing injured captain Marco Reus and top striker Paco Alcacer, gradually took control of proceedings and had the better chances in the first half.
Christian Pulisic fired at goalkeeper Hugo Lloris and the Frenchman brilliantly saved a point-blank header from Dan-Axel Zagadou before the interval.
But the hosts changed the course of the game within two minutes after the restart when they pounced on a defensive error.
Vertonghen whipped in a cross from the left for Son to volley home.
Dortmund, who had conceded just two goals in the group stage, tried to recover but found no way back.
Vertonghen then timed his run to perfection in the 83rd to kill off the game and Llorente gave Spurs what is likely an unassailable advantage.