Canberra and New Zealand Test forward Joe Tapine has been ruled out for 12 weeks of NRL football with an ankle injury.
Tapine limped from the field in the Raiders' win against Parramatta last Sunday and scans have revealed serious ligament damage.
He will miss Canberra's match against Brisbane on Sunday and won't return until at least round 15.
It continues an injury-plagued three years for the Kiwi, who has played just three of five games this season.
Raiders coach Ricky Stuart has been able to call on star English recruits John Bateman and Ryan Sutton to fill the void, and they'll be needed again against a desperate Broncos side.
JJ Collins is set to make his debut after he was named to replace Tapine on the interchange bench as Stuart's only change.
While the Raiders have flown out of the blocks with a 4-1 record in 2019 - their best start to a season in 14 years - the Broncos are 1-4.
Looking for a fourth straight win when they clash at GIO Stadium, Raiders co-captain Jarrod Croker said he expected the bounce-back factor to be significant for the struggling Brisbane side.
"They've been copping a lot, the Broncos," Croker said.
"But they're a big club, a powerful club. They're always a very strong team and I know they're no different this year. They've got a great forward pack and some quality halves and outside backs.
"They've lost a few on the bell and that just makes them more dangerous and more desperate."
The Raiders have dramatically turned around their form in 2019 and have the opposite record to this time last year, but Croker said they won't be getting ahead of themselves.
"We lost a lot of games by one or two points last year or by blowing leads, everyone was frustrated. So it's good to start the season well but there's still a lot to work on," Croker said.
"I think winning is infectious, a lot of sides going on winning streaks and sometimes you just find a way to win.
"You look at a side like the Panthers last year, they found themselves down in a lot of games but still winning them. It was infectious for them and hopefully it is for us.
"But we know things can change very quickly and we've spoke about that."