One person has been flown to hospital in Melbourne and another to taken Goulburn Valley Health after a car is believed to have lost control near Tatura overnight.
Shepparton Police said a single vehicle travelling on Tatura-Undera Rd, Tatura at around midnight is believed to have lost control passing through an intersection.
The vehicle is believed to have slid and collided with a tree, Shepparton Police said.
Authorities responded to the incident at approximately 12.20am this morning.
The driver was airlifted to hospital in Melbourne with non-life threatening injuries.
The passenger was transported to hospital in Shepparton via ambulance.