Emergency services are on the scene of a crash in the middle of the the intersection of Wyndham and High St, Shepparton.
A Mazda sedan and a CFA tanker are reported to have collided.
An ambulance was on scene but has now departed, while police are directing traffic.
Traffic travelling north on Wyndham St is being diverted onto High St.
Traffic travelling west on High St is also being impacted.
The scene is being cleared but there is still congestion.