Emergency services are on scene at a two-vehicle crash on the Goulburn Valley Hwy, north of Congupna.
Injuries are unknown at this stage.
Traffic travelling north is being diverted at Congupna on Katamatite-Shepparton Rd while southbound traffic is being diverted on Reynolds Rd.
Police, CFA crews and Shepparton Search and Rescue personnel are on scene.
Drivers are advised to avoid the area if possible.