Several CFA units are attending the scene of a fire in the very rear section of the old Mooroopna Base Hospital.
Police also attended the scene at around 4.30pm where vehicles worked from the Park St entrance, near the Mooroopna Museum and Historical Society.
Mooroopna CFA captain Ray Stockwell said investigations were ongoing into the cause of the blaze which was brought under control.
Mr Stockwell said emergency services were unaware of any occupants in the building at the time of the fire but it is believed there were no occupants.
Vehicles are encouraged to avoid the area.