Two people, believed to be a mother and son, have been injured in a crash on the Murray Valley Hwy at Kotupna.
Police said a male driver, 50, and a female passenger, 83, were travelling in a vehicle when it appeared the male driver lost control in slippery conditions and left the road and collided with a tree.
The woman is in a serious condition while the man sustained minor injuries. Both have been transported to GV Health hospital in Shepparton.
Police are diverting traffic through the scene.
Major crash investigators are due to attend the scene tonight.